CALL FOR PAPERS Cigarette Smoke-Induced Lung Endothelial and Alveolar Epithelial Injury Mechanisms of lung endothelial barrier disruption induced by cigarette smoke: role of oxidative stress and ceramides
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چکیده
Mechanisms of lung endothelial barrier disruption induced by cigarette smoke: role of oxidative stress and ceramides Kelly S. Schweitzer, Hadi Hatoum, Mary Beth Brown, Mehak Gupta, Matthew J. Justice, Besem Beteck, Mary Van Demark, Yuan Gu, Robert G. Presson, Jr., Walter C. Hubbard, and Irina Petrache Departments of Medicine and Anesthesiology, Indiana University School of Medicine, and Richard L. Roudebush Veterans Affairs Medical Center, Indianapolis, Indiana; Department of Medicine, Division of Clinical Pharmacology, The Johns Hopkins University, Baltimore, Maryland
منابع مشابه
Chinese green tea consumption reduces oxidative stress, inflammation and tissues damage in smoke exposed rats
Objective(s):One cause of cigarette smoking is oxidative stress that may alter the cellular antioxidant defense system, induce apoptosis in lung tissue, inflammation and damage in liver, lung, and kidney. It has been shown that Chinese green tea (CGT) (Lung Chen Tea) has higher antioxidant property than black tea. In this paper, we will explore the preventive effect of CGT on cigarette smoke-in...
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Cigarette smoking is a major risk factor in the development of various lung diseases, including pulmonary emphysema, pulmonary fibrosis, and lung cancer. The mechanisms of these diseases include alterations in alveolar epithelial cells, which are essential in the maintenance of normal alveolar architecture and function. Following cigarette smoking, alterations in alveolar epithelial cells induc...
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Previous studies demonstrated that CSE induces oxidative stress and its consequences on isolated mitochondria obtained from lung, heart and brain which may provide insight into the role of CSE in human health and disease. The present study was carried out to further characterize and compare toxic effect of CSE extract on isolated mitochondria obtained from either a directly contacting tissue (i...
متن کاملA Comparison of Toxicity Mechanisms of Cigarette Smoke on Isolated Mitochondria Obtained from Rat Liver and Skin
Previous studies demonstrated that CSE induces oxidative stress and its consequences on isolated mitochondria obtained from lung, heart and brain which may provide insight into the role of CSE in human health and disease. The present study was carried out to further characterize and compare toxic effect of CSE extract on isolated mitochondria obtained from either a directly contacting tissue (i...
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Although inflammation and protease/antiprotease imbalance have been postulated to be critical in cigarette smoke-induced (CS-induced) emphysema, oxidative stress has been suspected to play an important role in chronic obstructive pulmonary diseases. Susceptibility of the lung to oxidative injury, such as that originating from inhalation of CS, depends largely on its upregulation of antioxidant ...
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